a pain in the neck/ass 
不是真的指脖子/屁股疼
而是指令人讨厌/招人烦/让人蛋疼的人或事
日常出现频率挺高，因此千万不要误解为哪里疼哦。
a pain in the ass 相较 a pain in the neck 粗俗一点，但是使用频率可是相当高。
My boss is a real pain in the ass.
我老板真的很招人烦。
You can be a huge pain in the neck sometimes! 
你有时真的特招人烦。
This job is really becoming a pain in the neck. 
这件工作真的变得很让人蛋疼。

The original dispute was one of poetic diction... From an interest in the minor problem of poetic diction I was led to see that the problem was really one of a suitable medium for all branches of #Chinese literature#. The question now became: In what language shall the New China produce its future literature? My answer was: The classical language, so long dead, can never be the medium of a living literature of a living nation; the future literature of #China# must be written in the living language of the people. "No dead language can produce a living literature." And the living language I proposed as the only possible medium of the future literature of #China#, was the pei-hau, the vulgar tongue of the vast majority of the population, the language which, in the last 500 years, had produced the numerous novels read and loved by the people, though despised by the men of letters. I wanted this much despised vulgar tongue of the people and the novels to be elevated to the position of the national language of China, to the position enjoyed by all the modern national languages in #Europe#.

#Hu Shih# - #The Chinese Renaissance# (Chicago: #University of Chicago Press#, 1934), p. 50

The meaning of life lies not in how one is born, but in how one lives. That is the meaning of your life. If you get up and make up your mind to find the meaning of life, to create your own meaning of life, then you will have the meaning of one day as you live, and the meaning of another as you do one thing, and the meaning of life will be endless.

-- hu shi, what is the meaning of life https://t.cn/R0QqQF1