【Mol Psych：科学家开发出能测定神经元中蛋白质表达的特定方法】突触后蛋白（postsynaptic proteins）的组合性表达是神经元类型内部和之间突触多样性的基础，因此，神经元类型特异性的突触后蛋白质组的表征或许就是深入理解离散突触特性和选择性功能异常如何在突触病变中表现的关键。

近日，一篇发表在国际杂志Molecular Psychiatry上题为“Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice”的研究报告中，来自美国西北大学等机构的科学家们通过研究开发了一种新方法来测定单一神经元中的蛋白质表达，这一研究发现或能促使科学家们深入研究这一过程在疾病中是如何出现错误的。https://t.cn/A6TpieZj

#张艺兴工作室改名# 啊啊啊啊我来了‍♀️多彩的迪拜风光经典中东元素骆驼快来和@张艺兴 一起云游迪拜啦@张艺兴新歌Psychic0417上线 《Psychic》是我梦境里的旋律，充满异域神秘，沙漠，骆驼，超能力……是从未体会过的浪漫ᐅ II||II||II||II 请你听首歌▸︎:《Psychic》张艺兴Lay Zhang@张艺兴

【DNA Tandem Repeats as Iterable Objects to Count Cell Divisions: A Computational Model】
#论文发表#

#DNA#

#细胞分裂计数#

#表观遗传学#

Satellite DNA (satDNA), so named because DNA centrifugation over a density gradient forms a "satellite" band, consists of huge arrays of Tandem Repeats (TRs), i.e. sequences of non-coding DNA, each one made up of the repetition of its characteristic monomer. Many finding supports the hypothesis that TRs, together with DNA methylation, play a role in cell divisions and in early embryo cleavage (where counting cell division rounds is crucial). This paper therefore introduces a computational model to investigate the possible role of satellite DNA in counting cell divisions, showing how cells may operate under Boolean logic algebra.

DOI: 10.4236/psych.2024.154028 https://t.cn/A6TWhSwt