#brainnews[超话]#
STTT:华中科大刘恭平团队报道rhEPO改善APP/PS1小鼠认知障碍的新机制
来源:Autophagy Advances
近期,华中科技大学同济医学院基础医学院刘恭平教授团队在Signal Transduction and Targeted Therapy(IF=18.187)在线发表题为 “Recombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β”的论文,揭示了rhEPO通过上调HSP90β来拮抗APP/PS1小鼠脑内JNK/P38通路引起的神经元凋亡,同时减少Aβ负荷和逆转树突棘丢失,从而有助于改善APP/PS1小鼠的认知障碍。
![](https://wx3.sinaimg.cn/large/006kKxG4gy1h4305hkuz8j30p20dlta9.jpg)
STTT:华中科大刘恭平团队报道rhEPO改善APP/PS1小鼠认知障碍的新机制
来源:Autophagy Advances
近期,华中科技大学同济医学院基础医学院刘恭平教授团队在Signal Transduction and Targeted Therapy(IF=18.187)在线发表题为 “Recombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β”的论文,揭示了rhEPO通过上调HSP90β来拮抗APP/PS1小鼠脑内JNK/P38通路引起的神经元凋亡,同时减少Aβ负荷和逆转树突棘丢失,从而有助于改善APP/PS1小鼠的认知障碍。
![](https://wx3.sinaimg.cn/large/006kKxG4gy1h4305hkuz8j30p20dlta9.jpg)
Brown, G., & Robinson, S. L. (2010). Reactions to Territorial Infringement. Organization Science, 22(1), 210-224. doi:10.1287/orsc.1090.0507
In this study, Brown and Robinson empirically examined how territorial infringement leads to anger and reactionary defenses. Using a cognitive appraisal theory of anger, we posited that a perceived infringement evokes anger that, in turn, fuels reactionary defenses.
![](https://wx2.sinaimg.cn/large/005KNJl1ly1h1hqtynlouj32dl32ru0y.jpg)
In this study, Brown and Robinson empirically examined how territorial infringement leads to anger and reactionary defenses. Using a cognitive appraisal theory of anger, we posited that a perceived infringement evokes anger that, in turn, fuels reactionary defenses.
![](https://wx2.sinaimg.cn/large/005KNJl1ly1h1hqtynlouj32dl32ru0y.jpg)
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